Abstract: Objective: To analyze the risk factors for delayed bleeding after endoscopic resection of colorectal polyps, and to provide a
reference for clinical risk assessment and perioperative management. Methods: A retrospective analysis was conducted on 2 688 pa⁃
tients who underwent endoscopic colorectal polypectomy in the Endoscopy Center of the First People′s Hospital of Dali City from Janu⁃
ary 2021 to December 2022. General clinical characteristics, polyp features, and surgical information were collected. Patients were di⁃
vided into a bleeding group and a non-bleeding group according to the occurrence of delayed bleeding. Univariate analysis was per⁃
formed to identify associated factors, followed by multivariate Logistic regression to determine independent risk factors. Results:
Among 2 688 patients, delayed bleeding occurred in 55 cases, with an incidence rate of 2.05%, mostly occurring within 1-9 days post⁃
operatively. Univariate analysis showed that age, sex, body mass index (BMI), polyp diameter, location, and morphology were associated
with delayed bleeding (P<0.05). Multivariate Logistic regression indicated that male, younger age, BMI≥24 kg/m2, polyp diameter≥1 cm,
right-sided colonic location, and pedunculated polyps were independent risk factors for delayed bleeding. Conclusion: The incidence
of delayed bleeding after endoscopic resection of colorectal polyps is relatively low. However, male patients, younger individuals, those
who are overweight or obese, and patients with larger polyps, right-sided colorectal polyps, or pedunculated polyps have an increased
risk. Identifying high-risk patients and implementing targeted preventive measures can effectively reduce the risk of postoperative
bleeding and improve treatment safety.

Key words: colorectal polyps, delayed bleeding, endoscopic resection, risk factors, Logistic regression